Expression of p53 and MDM-2 Protein in Cervical Neoplasia.
- Author:
Chan Woo CHUNG
;
Yong Kag SHIN
;
Chae Woong PARK
;
Chang Joo KIM
;
Tae Il CHO
;
Eon Sub PARK
- Publication Type:Original Article
- Keywords:
Cervical neoplasia;
p53 protein;
MDM-2 protein;
p53;
MDM-2
- MeSH:
Carcinogenesis;
Humans;
Paraffin;
Proto-Oncogene Proteins c-mdm2*;
Tumor Suppressor Protein p53;
Uterine Cervical Neoplasms
- From:Korean Journal of Obstetrics and Gynecology
1999;42(10):2264-2269
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: MDM-2 is an oncoprotein that inhibits p53 tumor suppressor protein. Amplication and over- expression of its protein have been observed in human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To elucidate the role of p53 and MDM-2 protein in cervical neoplasia we investigated the expression rates of MDM-2 and p53 protein in surgically resected specimens. METHEDS: Immunohistochemical studies using anti-p53 and anti-MDM-2 protein in the paraffin embedded section of 62 cases including cervical intraepithelial neoplasm(CIN) and invasive cervical cancer were performed. RESULTS: Expression rates of p53 protein were 25% in CIN I& CINII, 20% in CINIII, and 44% in invasive carcinoma, respectively. The MDM-2 protein were 33% in CIN I & CIN II, 16% in CIN III, and 48% in invasive carcinoma, respectively. There was no evident correlation between p53 positivity and MDM-2 positivity(p>0.05). However, correlation between MDM-2 negativity and p53 negativity was statistically significant(p=0.002) CONCLUSION: These data suggest that the expression of p53 protein is presumed to be necessarily correlated with MDM-2 protein expression in cervical neoplasia.
