A case of the primary malignant melanoma arising from uterine endometrium.
- Author:
Ji Eun UHM
1
;
Tae Kyu LIM
;
Soojin CHO
;
Seung Tai KIM
;
Deok Soo BAE
;
Sang Yong SONG
;
Joon Oh PARK
Author Information
1. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. oncopark@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Endometrial neoplasm;
Melanoma
- MeSH:
Curettage;
Endometrial Neoplasms;
Endometrium*;
Female;
Humans;
Hysterectomy;
Korea;
Lymph Node Excision;
Melanoma*;
Middle Aged;
Positron-Emission Tomography;
S100 Proteins;
Uterine Hemorrhage
- From:Korean Journal of Medicine
2006;70(5):581-585
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Malignant melanoma arising in the uterine endometrium is extremely rare. Only 12 cases of malignant melanoma of the uterine endometrium have been previously reported to date. All of them were metastatic cases. The most common presenting symptom was abnormal uterine bleeding. We report a case of primary malignant melanoma arising from the uterine endometrium. A 63-year-old multigravid woman presented with uterine bleeding. The pathologic review of an endometrial curettage specimen suggested an undifferentiated malignant tumor. A total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection were performed. Final pathologic examination revealed malignant melanoma. Immunohistochemical studies demonstrated reactivity of tumor cells for HMB-45 and S-100 protein. She had no previous history of malignancy. Whole body PET scan was performed in an effort to find the primary site of malignant melanoma and showed no demonstrable abnormal FDG uptake suggesting malignancy elsewhere. This case is the first report of primary malignant melanoma involving uterine endometrium in Korea.
