A case of Stevens-Johnson syndrome caused by oxcarbazepine.
- Author:
Dong Ryeol RYU
1
;
Pil Sang SONG
;
Jin Young LEE
;
Ji Young RHEE
;
Mi Jung OH
;
Byung Jae LEE
;
Dong Chull CHOI
Author Information
1. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. dcchoi@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Oxcarbazepine;
Stevens-Johnson syndrome
- MeSH:
Aged;
Anticonvulsants;
Carbamazepine;
Humans;
Male;
Phenobarbital;
Phenytoin;
Skin;
Stevens-Johnson Syndrome*
- From:Korean Journal of Medicine
2006;70(5):586-590
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Stevens-Johnson syndrome and toxic epidermal necrolysis are acute life-threatening conditions. Aromatic antiepileptic drugs such as carbamazepine, phenytoin and phenobarbital are frequently associated with severe adverse cutaneous reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Oxcarbazepine, a 10-keto derivative of carbamazepine has been reported to have a similar range of efficacy and fewer side effects than carbamazepine because it is a prodrug of a monohydroxy derivative. Because there are few clinical records of oxcarbazepine induced erythemamultiforme-like skin eruptsions, we reported a case of Stevens-Johnson syndrome thought to be caused by the use of oxcarbazepine in a 66-year-old male. Diffuse erythematous maculopapular eruptions were developed on his whole body 30 days after beginning with oxcarbazepine. The clinical and histologic findings of the patient were compatible with Stevens-Johnson syndrome. Although it is rare, oxcarbazepine can cause severe adverse cutaneous reactions.
