The Frequency and Clinical Significance of Delayed Serological Transfusion Reactions in Korean Population.
- Author:
Tae Sung PARK
1
;
Chulhun L CHANG
;
Joo Seop CHUNG
;
Hune CHO
;
Eun Yup LEE
;
Han Chul SON
;
Hyung Hoi KIM
Author Information
1. Departments of Laboratory Medicine, College of Medicine, Pusan National University, Busan, Korea. hhkim@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
alloimmunization;
delayed hemolytic transfusion reaction;
delayed serological transfusion reaction;
prospective study;
medical alert card
- MeSH:
Antibody Formation;
Blood Group Incompatibility*;
Hemolysis;
Humans;
Incidence;
Isoantibodies;
Korea;
Mass Screening;
Medical Records;
Prospective Studies
- From:Korean Journal of Blood Transfusion
2005;16(1):20-31
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Alloantibodies to red cell antigens may cause acute or delayed hemolytic transfusion reactions (DHTRs). In most cases, however, anamnestic antibody production causes only a delayed serological transfusion reaction (DSTR). According to the previous reports, alloimmunization occured with a risk of 1-2.6%, however, no prospective studies on a DSTR have been performed in Korea. The purpose of this study was to evaluate prospectively the frequency of alloimmunization and its clinical significance in Korean population. METHODS: Antibody screening tests were performed for a total of 1,903 patients who were transfused with packed RBCs from May 2003 through July 2004. One blood sample from each patient was collected within 7-10 day after transfusion and screened for serological evidence of alloimmunization. If any antibody was detected the patient's post-transfusion sample was screened for biochemical evidence of hemolysis and the patients' medical records were reviewed for documentation of clinical signs of a transfusion reaction. RESULTS: Overall, 17/1,903 patients became alloimmunized for a frequency of 0.89%. Only one of 1,903 patients had clinical evidence of hemolysis, and the frequency of DHTR was 0.053%. Interestingly, anti-Dia which was characteristic antibody in Asian-Mongoloid populations was detected in three patients, and anti-Mia was found in one patient. CONCLUSION: This study showed lower frequency of DSTR and DHTR, compared with previous studies in Caucasian. However, it is noteworthy that the incidence of anti-Dia was relatively higher in Korean population.
