Efficacy of Imatinib Mesylate Neoadjuvant Treatment for a Locally Advanced Rectal Gastrointestinal Stromal Tumor.
10.3393/jksc.2011.27.3.147
- Author:
Kyu Jong YOON
1
;
Nam Kyu KIM
;
Kang Young LEE
;
Byung Soh MIN
;
Hyuk HUR
;
Jeonghyun KANG
;
Sarah LEE
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. namkyuk@yuhs.ac
- Publication Type:Case Report
- Keywords:
Gastrointestinal stromal tumors;
Imatinib;
Ultralow anterior resection;
Coloanal anastomosis;
Neoadjuvant treatment
- MeSH:
Benzamides;
Consensus;
Drug Resistance;
Gastrointestinal Stromal Tumors;
Humans;
Imatinib Mesylate;
Magnetic Resonance Imaging;
Mesylates;
Neoadjuvant Therapy;
Piperazines;
Pyrimidines;
Treatment Outcome
- From:Journal of the Korean Society of Coloproctology
2011;27(3):147-152
- CountryRepublic of Korea
- Language:English
-
Abstract:
Surgery is the standard treatment for a primary gastrointestinal stromal tumor (GIST); however, surgical resection is often not curative, particularly for large GISTs. In the past decade, with imatinib mesylate (IM), management strategies for GISTs have evolved significantly, and now IM is the standard care for patients with locally advanced, recurrent or metastatic GISTs. Adjuvant therapy with imatinib was recently approved for use, and preoperative imatinib is an emerging treatment option for patients who require cytoreductive therapy. IM neoadjuvant therapy for primary GISTs has been reported, but there is no consensus on the dose of the drug, the duration of treatment and the optimal time of surgery. These are critical because drug resistance or tumor progression can develop with a prolonged treatment. This report describes two cases of large rectal malignant GISTs, for which a abdominoperineal resection was initially anticipated. The two patients received IM preoperative treatment; we followed-up with CT or magnetic resonance imaging to access the response. After 9 months of treatment, a multi-disciplinary consensus that maximal benefit from imatinib had been achieved was reached. We determined the best time for surgical intervention and successfully performed sphincter-preserving surgery before resistance to imatinib or tumor progression occurred. We believe that a multidisciplinary team approach, considerating the optimal duration of therapy and the timing of surgery, is required to optimize treatment outcome.
