Concurrent Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ascending Colon: A Case Report.
10.3393/jksc.2011.27.3.157
- Author:
Yo Na KIM
1
;
Ho Sung PARK
;
Kyu Yun JANG
;
Woo Sung MOON
;
Dong Geun LEE
;
Ho LEE
;
Min Ro LEE
;
Kyung Ryoul KIM
Author Information
1. Department of Pathology, Research Institute for Endocrine Science, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea. hspark@chonbuk.ac.kr
- Publication Type:Case Report
- Keywords:
Colon neoplasms;
Carcinoma, Neuroendocrine;
Adenocarcinoma
- MeSH:
Abdomen;
Abdominal Pain;
Adenocarcinoma;
Aged;
Carcinoma, Neuroendocrine;
Chromogranin A;
Colon;
Colon, Ascending;
Colonic Neoplasms;
Cytoplasm;
Eosinophils;
Humans;
Laparotomy;
Mitosis;
Necrosis;
Synaptophysin;
Tomography, Spiral Computed;
Ulcer
- From:Journal of the Korean Society of Coloproctology
2011;27(3):157-161
- CountryRepublic of Korea
- Language:English
-
Abstract:
Large cell neuroendocrine carcinomas of the colon are rare and represent only a small percentage of all colonic endocrine tumors. Here, we report a case of a colonic large cell neuroendocrine carcinomas concurrent with a colonic adenocarcinoma. A 70-year-old man presented with acute abdominal pain. A spiral computed tomography scan of the abdomen revealed eccentric wall thickening on the ascending colon. An explorative laparotomy and a right hemicolectomy were performed. Grossly, two separated masses were observed in the proximal ascending colon. One was a 7.4 x 5.1 cm ulcerative fungating lesion, and the other was a 2.8 x 1.9 cm polypoid lesion. Microscopically, the ulcerative fungating lesion showed a well-differentiated neuroendocrine morphology with necrosis and increased mitosis. Most of the tumor cells had large, vesicular nuclei with eosinophilic nucleoli, variable amounts of eosinophilic cytoplasm, and immunoreactivity for chromogranin A and synaptophysin. The polypoid lesion was a well-differentiated adenocarcinoma that had invaded the submucosa. We diagnosed these lesions as a concurrent large cell neuroendocrine carcinoma and an adenocarcinoma of the ascending colon.