Osteopontin and Developing Kidney.
- Author:
Hyung Eun YIM
1
;
Kee Hwan YOO
Author Information
1. Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea. guroped @korea.ac.kr
- Publication Type:Review
- Keywords:
Osteopontin;
UUO;
Neonatal kidney
- MeSH:
Acute Kidney Injury;
Bone Remodeling;
Cell Adhesion;
Cell Survival;
Endothelial Cells;
Epithelial Cells;
Glomerulonephritis;
Hypertension;
Kidney*;
Macrophages;
Osteopontin*;
Wounds and Injuries
- From:Journal of the Korean Society of Pediatric Nephrology
2006;10(1):1-7
- CountryRepublic of Korea
- Language:English
-
Abstract:
Osteopontin (OPN) is a glycosylated phosphoprotein which mediates cell adhesion and migration, and is produced by bone, macrophages, endothelial cells, and epithelial cells. The many regulatory functions of OPN include bone remodeling, tumor invasion, wound repair, and promotion of cell survival. It is produced by renal tubular epithelial cells, and expression is upregulated in glomerulonephritis, hypertension, ischemic acute renal failure, renal ablation, and UUO. In this review, we discuss about osteopontin in general aspect, expression, role on the development and pathologic condition of neonatal kidney.
