The Effect of Intraluminal Oxygen Insufflation on the Oxygenation of Gut Mucosa in Hemorrhaged Cats.
10.4097/kjae.1996.31.4.411
- Author:
Yu Mee LEE
1
;
Pyung Hwan PARK
;
Joung Uk KIM
;
Sam Soon JO
Author Information
1. Department of Anesthesiology, College of Medicine, University of Ulsan, Korea.
- Publication Type:Original Article
- Keywords:
Shock hemorrhagic;
Oxygen insufflation;
Oxygenation intestinal mucosa
- MeSH:
Animals;
Cats*;
Insufflation*;
Lactic Acid;
Mucous Membrane*;
Oxygen*;
Reperfusion;
Shock;
Shock, Hemorrhagic
- From:Korean Journal of Anesthesiology
1996;31(4):411-417
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study was purposed to study the therapeutic value of intraluminal oxygen insufflation on the oxygenation of gut mucosa in a feline model subjected to a hemorrhagic shock followed by reperfusion. METHODS: Eighteen cats were divided into three groups : For group 1, 6 cats were subjected to sham operation as a control group ; for group 2, 6 cats were subjected to a hemorrhagic shock for 2 hours prior to reperfusion as a hemorrhagic shock(HS) group ; for group 3, 6 cats were subjected to a simultaneous insufflation of intraluminal oxygen, continued during the shock and reperfusion periods as a oxygenated hemorrhagic shock(OHS) group. Mesenteric PvO2, mesenteric venous arterial(v-a) lactate difference, mesenteric P(v-a)CO2 and mesenteric pH(a-v) were measured for every 30 minutes during the shock and reperfusion. RESULTS: The lactate(v-a) was increased during the shock. For group OHS, the lactate(v-a) returned to the baseline value after reperfusion, but for group HS, it did not return. The values of pH(v-a) and P(v-a)CO2 were increased during the shock and returned to the baseline value for group OHS, but for group HS, the increase was greater than group OHS(p<0.05), but not returned to the baseline value after reperfusion. For both pH(v-a) and P(v-a)CO2, there were statistically significant differences(p<0.05) between group HS and group OHS during the shock and reperfusion. CONCLUSIONS: We conclude that the insufflation of intraluminal oxygen improves the oxygenation of gut mucosa in the feline model undergone a hemorrhagic shock followed by reperfusion.
