Hydoroxocobalamin (Vitamin B12) Effects on Nerve Function Impairments in Leprosy.
- Author:
Kyung Duk LEE
1
Author Information
1. Sokdo National Hospital, Korea. sorok38@sorokdo.go.kr
- Publication Type:Original Article
- Keywords:
Leprosy;
Nerve function impairment;
Neuralgia;
Tremor;
Hydroxocobalamin(Vitamin B12)
- MeSH:
Congenital Abnormalities;
Hand;
Humans;
Hydroxocobalamin;
Jaw;
Leprosy;
Myelin Sheath;
Neuralgia;
Peripheral Nervous System Diseases;
Sweat;
Sweating;
Tremor;
Vitamin B 12
- From:Korean Leprosy Bulletin
2008;41(2):17-22
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
95 patients in Sorokdo national hospital injected 1-5mg Hydroxocobalamin (5mg/2ml/1ample) in 5-7 days/week, duration 6.4 months, average age 71.6 years old. Effects are 1) softening of hand movement(22/95), early effect, 2) improving of motor function (8/95) 3) sensory function(8/95) 4) sweating (3/95) 5) neuropathic pain and headache(neuralgia-like) (7/95) 6) jaw and hand tremor (7/95) 7) no response (41/95) 8) side effect (1/95) Leprosy is demyelinating peripheral neuropathy, Vitamin B12 effects on myelin, but unkown it's mechnism. Vitamin B12 improve nerve function impairments in leprosy, especially neuropathic pain and tremor, which lead to deformities and disabilities.
