A Case of Classic Polyarteritis Nodosa Presented with Acute Renal Failure.
- Author:
Tae Woon PARK
1
;
Myoung Lyeol WOO
;
Seo Goo HAN
;
Jeong Hun KIM
;
Byung Soo JEON
;
Sang Cheol LEE
;
Ji Sun SONG
;
Soo Young YOON
Author Information
1. Departments of Internal Medicine, Kwandong University College of Medicine, Goyang Gyeonggi, Korea. diva502@kd.ac.kr
- Publication Type:Case Report
- Keywords:
Classic polyarteritis nodosa;
Acute renal failure;
Anti-neutrophil cytoplasmic antibody
- MeSH:
Acute Kidney Injury*;
Antibodies, Antineutrophil Cytoplasmic;
Arteries;
Asthenia;
Biopsy;
Creatinine;
Cyclophosphamide;
Diagnosis;
Hospitalization;
Humans;
Inflammation;
Male;
Methylprednisolone;
Microscopic Polyangiitis;
Middle Aged;
Necrosis;
Polyarteritis Nodosa*;
Renal Dialysis;
Renal Insufficiency
- From:Korean Journal of Nephrology
2006;25(6):1029-1034
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Classic polyarteritis nodosa (c-PAN), first described by Kussmaul and Maier in 1866, is a systemic illness characterized by necrotizing inflammation of medium- sized arteries. Rapid progressive renal failure is very rare in c-PAN in contrast to microscopic polyangiitis (MPA). We report a case of c-PAN presented with rapidly progressive renal failure. A 58 year-old male was referred to our hospital for evaluation of asthenia and right visual loss. An increase in serum creatinine level was developed in the 6th day of hospitalization and acute renal failure was aggravated rapidly. Renal biopsy showed the transmural fibrinoid necrosis of small and medium sized arteries with few glomerular crescents. P-ANCA was detected in serum, and all clinical and laboratory findings supported the diagnosis of c-PAN. He was treated with pulse methylprednisolone, followed by oral corticosteroid and cyclophosphamide, and received temporary hemodialysis. After the treatment, he recovered and was discharged but his visual defect was irreversible despite the treatment.
