Expression of E-cadherin and Clinical Correlation in Patients with Breast Carcinoma.
10.4048/jkbcs.2004.7.3.148
- Author:
Jung Man KIM
1
;
Tae Yoon KIM
;
Dan SONG
;
Sung Yong KIM
;
Moo Jun BAEK
;
Moon Soo LEE
;
Chang Ho KIM
;
Seung Ha YANG
;
Min Hyuk LEE
;
Moo Sik CHO
Author Information
1. Department of Surgery, College of Medicine, Soonchunhyang University, Cheonan, Korea. sykim@schch.co.kr
- Publication Type:Original Article
- Keywords:
Breast cancer;
E-cadherin
- MeSH:
Animals;
Breast Neoplasms*;
Breast*;
Cadherins*;
Cell Adhesion;
Growth and Development;
Humans;
Lymph Nodes;
Mice;
Multivariate Analysis;
Negotiating;
Prognosis
- From:Journal of Korean Breast Cancer Society
2004;7(3):148-153
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: E-cadherin is a Ca (2+)-dependent cell adhesion molecule that plays an important role in normal growth and development via the mediation of homotypic, homophilic cell-cell interactions. Recent studies suggest that E-cadherin may also be important in neoplastic progression, particularly as a suppressor of invasion. METHODS: To evaluate the expression of E-cadherin, according to the histopathological features and the relation between E-cadherin and prognosis in breast carcinoma, immunohistochemical staining, using mouse HECD-1 was performed for 66 cases of breast carcinoma. RESULTS: The breast carcinomas showed loss or marked reduction of E-cadherin expression in 42 (63.6%) of the 66 cases. In a multivariate analysis, E-cadherin expression had no independent prognostic value, while the axillary lymph node status, tumor diameter, and TNM stage were independent prognostic factors. The results indicate that E-cadherin expression was related to several histological features in breast cancer, but had no independent prognostic value over standard prognostic factors. No significant correlation was found between E-cadherin expression and tumor size, stage, nuclear grade, lymph node status, histologic type, or hormonal status. CONCLUSION: The loss or marked reduction of E-cadherin expression in breast carcinomas was not related to the prog nosis of the patients.
