Pulsed Dye Laser Treatment Combined with Oral Minocycline Reduces Recurrence Rate of Rosacea.
- Author:
Hye Soo KO
1
;
Young Ju SUH
;
Ji Won BYUN
;
Gwang Seong CHOI
;
Jeonghyun SHIN
Author Information
- Publication Type:Original Article
- Keywords: Minocycline; Pulsed dye laser; Recurrence; Rosacea; Therapeutics
- MeSH: Humans; Lasers, Dye*; Methods; Minocycline*; Proportional Hazards Models; Protective Factors; Recurrence*; Retrospective Studies; Risk Factors; Rosacea*
- From:Annals of Dermatology 2017;29(5):543-547
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: The recurrence rate of rosacea was not known very well, but has been reported as 60% in 6 months after withdrawal of the drug. It is not known which treatment can reduce relapses of rosacea effectively. OBJECTIVE: The objective was to identify whether 595 nm-pulsed dye laser (PDL) treatment reduced recurrence rate among rosacea patients who were treated with oral minocycline. METHODS: One hundred and seven Korean patients with rosacea who started treatment with oral minocycline (100 mg/d) with or without PDL (2∼4 sessions) were evaluated retrospectively. The recurrence rate was estimated using the Kaplan-Meier method, and difference was evaluated using the log-rank test. Cox proportional hazards model was used to estimate hazard ratios and 95% confidence intervals (CIs) of risk factors for the recurrence of rosacea. RESULTS: The recurrence-free survival analysis revealed that the group with oral minocycline plus PDL was significantly different compared with the group with oral minocycline alone (p=0.011). Cox proportional hazards model showed that the combined use of PDL with oral minocycline appeared to be a significant protective factor for the hazard of recurrence of rosacea (hazard ratio, 0.492; 95% CI, 0.257∼0.941; p=0.032). CONCLUSION: PDL can be used added to oral minocycline to reduce relapses among rosacea patients who are undergoing oral minocycline treatment.
