A Case Of Primary Gastric Choriocarcinoma Associated With Adenocarcinoma.
- Author:
Sang Won LEE
1
;
Sung Jae KIM
;
Sun Hyo PARK
;
Young Rok DO
;
Hong Suk SONG
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. shs7436@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Choriocarcinoma;
Non-gestational
- MeSH:
Abdomen;
Adenocarcinoma*;
Biopsy;
Bleomycin;
Brain;
Breast;
Choriocarcinoma*;
Choriocarcinoma, Non-gestational;
Cisplatin;
Diagnosis;
Drug Therapy, Combination;
Etoposide;
Female;
Gastrectomy;
Gastroenterostomy;
Gastrointestinal Tract;
Germ Cells;
Gonads;
Humans;
Kidney;
Liver;
Lung;
Lymph Nodes;
Mediastinum;
Middle Aged;
Neoplasm Metastasis;
Neoplasms, Glandular and Epithelial;
Pineal Gland;
Pregnancy;
Pregnancy, Ectopic;
Prostate;
Stomach;
Tomography, X-Ray Computed;
Trophoblasts;
Urinary Bladder;
Uterus;
Vagina
- From:Korean Journal of Medicine
2005;68(1):83-88
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Choriocarcinoma is a HCG-producing epithelial neoplasm derived from either trophoblastic or totipotential germ cells. It is a highly malignant tumor, which is rapidly invasive and widely metastatic, and in most cases develops within the uterus after a normal or abnormal gestation, including ectopic pregnancy. Non-gestational choriocarcinoma rarely occur as a primary neoplasm in the gonads or in the extragonadal midline locations such as mediastinum, retroperitoneum, and pineal gland. It also has been reported very rarely to arise in parenchymal organs such as the prostate, lung, breast, brain, liver, kidney, bladder, vagina, and gastrointestinal tract. A 58-year old man was admitted to our hospital with symptoms of tarry stool and epigastric discomfort. The endoscopic biopsy specimen initially revealed pooly differentiated carcinoma of stomach with regional lymph node metastasis. Patient underwent distal gastrectomy with Billroth II anastomosis. Choriocarcinoma of stomach with well differentiated tubular adenocarcinoma was diagnosed by the surgical biopsy specimen, and the serum level of beta-HCG was 2,775 mIU/mL.In three months after operation, the patient presented with pain on right upper quadrant abdomen, and the CT scan revealed multiple liver metastasis. Bleomycin, etoposide, and cisplatin (BEP) combination chemotherapy were administered, but he died three months after the initial diagnosis.
