Helicobacter heilmannii-associated Gastritis: Clinicopathologic Findings and Comparison with Helicobacter pylori-associated Gastritis.
10.3346/jkms.2007.22.1.63
- Author:
Mee JOO
1
;
Ji Eun KWAK
;
Sun Hee CHANG
;
Hanseong KIM
;
Je G CHI
;
Kyung Ah KIM
;
Jeon Ho YANG
;
June Sung LEE
;
Young Soo MOON
;
Kyoung Mee KIM
Author Information
1. Department of Pathology, College of Medicine, Inje University Ilsanpaik Hospital, Goyang, Korea. meeah@hitel.net
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Helicobacter heilmannii;
Helicobacter pylori;
Gastritis;
Lymphoma, Mucosa-Associated Lymphoid Tissue;
Parietal Cells, Gastric
- MeSH:
Stomach Neoplasms/etiology/pathology;
Middle Aged;
Male;
Lymphoma, Mucosa-Associated Lymphoid Tissue/etiology/pathology;
Humans;
*Helicobacter pylori;
*Helicobacter heilmannii;
Helicobacter Infections/*pathology;
Gastritis/*pathology;
Female;
Adult
- From:Journal of Korean Medical Science
2007;22(1):63-69
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aims of this study were to evaluate the clinicopathologic features of Helicobacter heilmannii-associated gastritis and to compare H. heilmannii-associated gastritis with H. pylori-associated gastritis. We reviewed 5,985 consecutive gastric biopsy specimens. All cases of chronic gastritis with Helicobacter infection were evaluated with the Updated Sydney System, and the grades of all gastritis variables were compared between H. heilmannii-associated gastritis and H. pylori-associated gastritis groups. There were 10 cases of H. heilmannii-associated gastritis (0.17%) and 3,285 cases of H. pylori-associated gastritis (54.9%). The organisms were superficially located within the mucous layer without adhesion to epithelial cells. Interestingly, in one case many intracytoplasmic H. heilmannii organisms were observed in parietal cells with cell damage. A case of low-grade mucosa-associated lymphoid tissue (MALT) lymphoma concomitant with H. heilmannii infection was detected. Compared to H. pylori-associated gastritis, H. heilmannii-associated gastritis showed less severe neutrophilic activity (p<0.0001), mononuclear cell infiltration (p=0.0029), and endoscopic findings of chronic gastritis devoid of erosion or ulcer (p=0.0309). In conclusion, we present the detailed clinicopathologic findings of H. heilmanniiassociated gastritis compared to H. pylori-associated gastritis. H. heilmannii-associated gastritis is uncommon and milder than H. pylori-associated gastritis, however it may be noteworthy with respect to the development of MALT lymphoma.