Cancer-preventive Properties of an Anthocyanin-enriched Sweet Potato in the APCMIN Mouse Model.
10.15430/JCP.2017.22.3.135
- Author:
Khalid ASADI
1
;
Lynnette R. FERGUSON
;
Martin PHILPOTT
;
Nishi KARUNASINGHE
Author Information
1. Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. asadik@xtra.co.nz
- Publication Type:Original Article
- Keywords:
Anthocyanins;
Sweet potato;
Colorectal cancer;
APCMIN mice;
cancer Protection
- MeSH:
Adenoma;
Animals;
Anthocyanins;
Colorectal Neoplasms;
Diet;
Intestines;
Ipomoea batatas*;
Mice*;
Models, Genetic;
New Zealand;
Skin
- From:Journal of Cancer Prevention
2017;22(3):135-146
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Anthocyanin-rich foods and preparations have been reported to reduce the risk of life-style related diseases, including cancer. The SL222 sweet potato, a purple-fleshed cultivar developed in New Zealand, accumulates high levels of anthocyanins in its storage root. METHODS: We examined the chemopreventative properties of the SL222 sweet potato in the C57BL/6J-APC(MIN/+) (APC(MIN)) mouse, a genetic model of colorectal cancer. APC(MIN) and C57BL/6J wild-type mice (n=160) were divided into four feeding groups consuming diets containing 10% SL222 sweet potato flesh, 10% SL222 sweet potato skin, or 0.12% ARE (Anthocyanin rich-extract prepared from SL222 sweet potato at a concentration equivalent to the flesh-supplemented diet) or a control diet (AIN-76A) for 18 weeks. At 120 days of age, the mice were anaesthetised, and blood samples were collected before the mice were sacrificed. The intestines were used for adenoma enumeration. RESULTS: The SL222 sweet potato-supplemented diets reduced the adenoma number in the APC(MIN) mice. CONCLUSIONS: These data have significant implications for the use of this sweet potato variant in protection against colorectal cancer.
