Biochemical and Biological Progress in the Studies of Keratinization and Dyskeratosis.
- Author:
Ogawa HIDEOKI
;
Takamori KENJI
;
Negi MAKOTO
;
Takashi YOSHIIKE
- Publication Type:Original Article
- Keywords:
Keratin;
Keratinization;
Dyskeratosis
- MeSH:
Cell Membrane;
Darier Disease;
Fetus;
Hyperkeratosis, Epidermolytic;
Ichthyosis;
Ichthyosis Vulgaris;
Ichthyosis, Lamellar;
Keratinocytes;
Lysine;
Psoriasis
- From:Korean Journal of Dermatology
1985;23(4):429-440
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recent topics of biochemical and biological progress in keratinization and dyskeratosis were reviewed and discussed. The main topics were as follows: (1) what is keratin (2) Differentiation of keratinocytes (keratinization), (3) Components of horny substances and their derivation, (4) Keratin filament and keratohyaline granule, (5) Synthesis of horny cell membrane (disulfide bonds, e- (T-glutamyl) lysine bonds), (6) Biochernical analysis of dyskeratosis (harlequin fetus, ichthyosis vulgaris, X-linked ichthyosis, lamellar ichthyosis, bullous congenital ichthyosiform erythroderma, psoriasis vulgaris, Dariers disease, M:enke's syndrome, Netherton's disease, Richner-Hanhart syndrome). These findings should lead to a more cornplete understanding of the pathologic events that occur in the process of keratinization and more rational therapy for many disorders in keratinization.
