Effect of Initial Empirical Antibiotics Duration on Neonatal Outcomes in Very Low Birth Weight Infants.
- Author:
Nury BAG
1
;
Myo Jing KIM
Author Information
1. Department of Pediatrics, Dong-A University College of Medicine, Busan, Korea. neonate.kr@gmail.com
- Publication Type:Original Article
- Keywords:
Antibiotics;
Infant;
very low birth weight;
Outcomes
- MeSH:
Anti-Bacterial Agents;
Birth Weight;
Enteral Nutrition;
Humans;
Incidence;
Infant;
Infant, Very Low Birth Weight;
Medical Records;
Retrospective Studies;
Sepsis
- From:Korean Journal of Perinatology
2012;23(2):69-75
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Little is known about the duration of antibiotics for suspected early-onset sepsis (EOS) with negative blood cultures. The purpose of this study is to identify associations between the duration of empirical antibiotics and neonatal outcomes. METHODS: We retrospectively reviewed medical records of very low birth weight infants (VLBW) who admitted to NICU in 2007-2010. We defined empirical antibiotic therapy group as those who started antibiotic therapy in first 3 postnatal days. We compared the neonatal outcomes between short empirical antibiotic therapy (<5 days) and long empirical antibiotic therapy (> or =5 days). RESULTS: Of 122 VLBW, 72 infants were long empirical antibiotic therapy group. In the long empirical antibiotic therapy group, there were lower birth weight, higher rate of out-born, higher rate of vaginal delivery, and had lower Apgar scores. Prolonged antibiotic therapy was associated with delayed start of enteral feeding and incidence of ESBL. CONCLUSION: Prolonged antibiotic therapy may be associated with some adverse neonatal outcomes. Therefore, wide spread agreement regarding the short empirical antibiotic therapy was needed.
