The Efficacy of Levofloxacin Based Triple Therapy for Helicobacter pylori Eradication.
- Author:
Ji Hyun LEE
1
;
Sung Pyo HONG
;
Chang Il KWON
;
Lea Hyun PHYUN
;
Byoung Sok LEE
;
Han Ul SONG
;
Kwang Hyun KO
;
Seong Gyu HWANG
;
Pil Won PARK
;
Kyu Sung RIM
;
Sehyun KI
Author Information
1. Department of Internal Medicine, Bundang CHA Hospital, Pochon CHA University College of Medicine, Seongnam, Korea. sphong@cha.ac.kr
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
Levofloxacin;
Eradication therapy
- MeSH:
Adult;
Aged;
Anti-Bacterial Agents/*administration & dosage;
Drug Therapy, Combination;
Female;
Helicobacter Infections/*drug therapy;
*Helicobacter pylori;
Humans;
Male;
Middle Aged;
Ofloxacin/*administration & dosage
- From:The Korean Journal of Gastroenterology
2006;48(1):19-24
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The failure rates of first and second line therapies of Helicobacter pylori (H. pylori) eradication range from 15 to 20%. This study was aimed to evaluate the efficacy and safety of levofloxacin based triple therapy compared with standard triple or quadruple therapy for H. pylori eradication in Korea. METHODS: We enrolled two hundred and sixty seven patients with presence of H. pylori infection. One hundred and forty-one patients were treated with levofloxacin based triple therapy (LAP; levofloxacin, amoxicillin, proton pump inhibitor; PPI), and 126 patients were treated with standard triple therapy (CAP; clarithromycin, amoxicillin, PPI). We retreated the patients who had failed in H. pylori eradication with standard quadruple second-line therapy (MTPB; metronidazole, tetracycline, PPI, bismuth subcitrate) or levofloxacin based therapy (LAP or LCP; levofloxacin, clarithromycin, PPI). RESULTS: In first line therapy of H. pylori eradication, the eradication rates of levofloxacin based triple therapy and standard triple therapy were 69.8% and 74.0% respectively (p=0.52). In second-line therapy, the eradication rate of levofloxacin based triple therapy and standard quadruple therapy were 62.5% and 40.0% respectively (p=0.34). CONCLUSIONS: Levofloxacin based triple therapy is effective as standard regimen to eradicate H. pylori infection and is useful for an alternative rescue therapy as well.
