Transcription Factors in the Cellular Signaling Network as Prime Targets of Chemopreventive Phytochemicals.
- Author:
Young Joon SURH
1
Author Information
1. National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University Seoul, Korea. surh@plaza.snu.ac.kr
- Publication Type:Review
- Keywords:
Chemoprevention;
Phytochemicals;
Signal transduction;
Cell signaling network;
NF- kappa B;
AP-1;
Mitogen-activated protein kinases;
Nrf2;
Keap1
- MeSH:
Chemoprevention;
Fruit;
Mitogen-Activated Protein Kinases;
Phytochemicals*;
Plants, Edible;
Signal Transduction;
Transcription Factor AP-1;
Transcription Factors*;
Vegetables
- From:Cancer Research and Treatment
2004;36(5):275-286
- CountryRepublic of Korea
- Language:English
-
Abstract:
Accumulating evidence from epidemiologic and laboratory studies support an inverse relationship between a regular consumption of fruits and vegetables and the risk of specific cancers. Numerous phytochemicals derived from edible plants have been reported to possess ability to interfere with a specific stage of carcinogenic process. Multiple mechanisms have been proposed to account for the anti-carcinogenic actions of dietary constituents, but more attention has recently focussed on intracellular signaling cascades as common molecular targets of a wide variety of chemopreventive phytochemicals.
