Activity of Moxifloxacin Against Ofloxacin-Resistant Mycobacterium Tuberculosis: A Study of Cross-Resistance Between Ofloxacin and Moxifloxacin.
10.4046/trd.2004.57.5.405
- Author:
Byoung Ju KIM
1
;
Young Soo KANG
;
Seung Kyu PARK
Author Information
1. Clinical Research Center for Tuberculosis, National Masan Hospital, Masan, Korea. pulmo116@empal.com
- Publication Type:Original Article
- Keywords:
moxifloxacin;
ofloxacin;
quinolone;
cross-resistance;
tuberculosis
- MeSH:
Humans;
Mycobacterium tuberculosis*;
Mycobacterium*;
Ofloxacin*;
Quinolones;
Tuberculosis;
Tuberculosis, Multidrug-Resistant
- From:Tuberculosis and Respiratory Diseases
2004;57(5):405-410
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Moxifloxacin is an 8-methoxyquinolone compound which has been shown to have the best activity of the quinolones against M. tuberculosis but there is no literature showing the rate of cross-resistance between moxifloxacin and the other quinolones such as ofloxacin. Therefore, we tested the activity of moxifloxacin against ofloxacin resistant M. tuberculosis by a study of cross-resistance. METHODS: We tested MIC's of moxifloxacin and ofloxacin by proportion method against 34 M. tuberculosis isolates showing resistance against ofloxacin at 2.5microgram/ml concentration and 13 ofloxacin susceptible isolates from specimens submitted to clinical laboratory of National Masan Hospital from March 2003 to March 2004. RESULTS: For ofloxacin susceptible isolates, MIC(50) and MIC(90) of ofloxacin were all 1.25 microgram/ml, and MIC(50) and MIC(90) of moxifloxacin were 0.31 microgram/ml and 0.63microgram/ml respectively. For ofloxacin resistant isolates, MIC(50) of ofloxacin was over 10microgram/ml and MIC(50) of moxifloxacin was 5microgram/ml,MIC(90) of ofloxacin and moxifloxacin were all over 10microgram/ml. The rate of cross-resistance between the two was 67.6%(23/34) at 2.5microgram/ml concentration. CONCLUSIONS: Moxifloxacin showed activity against 82.4%(28/34) of ofloxacin resistant M. tuberculosis at 10microgram/ml, but more studies are needed so that moxifloxacin will be used for patient with multi-drug resistant tuberculosis including ofloxacin resistance.
