Disseminated Invasive Aspergillosis with Multiple Brain Abscess after Allogeneic Hematopoietic Stem Cell Transplantation Treated Successfully with Voriconazole and Neurosurgical Intervention.
- Author:
Jae Hyoung IM
1
;
In Suh PARK
;
Eun Young KIM
;
Jin Soo LEE
;
Joo Han LIM
;
Moon Hee LEE
;
Chul Soo KIM
;
Hyeon Jung LEE
;
Hyeon Gyu YI
Author Information
- Publication Type:Case Report
- Keywords: Invasive aspergillosis; Central nervous system; Hematopoietic stem cell transplantation; Neurosurgical procedure; Voriconazole
- MeSH: Aspergillosis; Brain; Brain Abscess; Central Nervous System; Drainage; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Lung; Neurosurgical Procedures; Pyrimidines; Stress, Psychological; Triazoles
- From:Infection and Chemotherapy 2012;44(5):395-398
- CountryRepublic of Korea
- Language:English
- Abstract: Invasive aspergillosis is a serious infectious complication, which can occur after hematopoietic stem cell transplantation (HSCT). In particular, despite antifungal treatment, invasive aspergillosis involving the central nervous system (CNS) shows very high mortality. In principle, a neurosurgical procedure with an antifungal agent is recommended for treatment of CNS invasive aspergillosis. We encountered a patient suffering from disseminated invasive aspergillosis involving the lung, brain, and soft tissues after allogeneic HSCT for treatment of relapsed acute myeloid leukemia who was cured with voriconazole and stereotactic drainage of the brain abscess.
