The First Case of Abacavir Hypersensitivity Associated with the HLA-B*57:01-Positive Allele in Korea.
- Author:
Ji Hyun YOON
1
;
Mingoo KIM
;
Sung Joon JIN
;
Seung Kyu KIM
;
Seo Hui LEE
;
Jaeyoung CHEON
;
Gi Young YUN
;
Min Kyung KIM
;
Jiyoon HA
;
Young Goo SONG
Author Information
- Publication Type:Case Report
- Keywords: Abacavir; Hpersensitivity; HLA-B*57:01; Korea
- MeSH: Abdominal Pain; Alleles; Diarrhea; Dideoxynucleosides; Exanthema; Fever; Hematologic Tests; Hepatitis; Humans; Hypersensitivity; Korea; Liver; Male; Renal Insufficiency
- From:Infection and Chemotherapy 2012;44(5):399-402
- CountryRepublic of Korea
- Language:English
- Abstract: On the 12th day of abacavir treatment, a 39-year old HIV-infected male patient was admitted with fever, generalized rash, abdominal pain, and watery diarrhea that had persisted for five days. Results of blood tests indicated rapid progression of hepatitis and renal failure. The day after stopping anti-retroviral therapy, his fever subsided and his liver function began to normalize. He was clinically diagnosed with abacavir hypersensitivity and was found to carry the HLA-B*57:01 allele. This is the first reported case of abacavir hypersensitivity associated with the presence of the HLA-B*57:01 allele in Korea.
