Ovarian cancer mortality among women aged 40-79 years in relation to reproductive factors and body mass index: latest evidence from the Japan Collaborative Cohort study.
10.3802/jgo.2013.24.3.249
- Author:
Md Mobarak Hossain KHAN
1
;
Aklimunnessa KHAN
;
Masahiro NOJIMA
;
Sadao SUZUKI
;
Yoshihisa FUJINO
;
Shinkan TOKUDOME
;
Koji TAMAKOSHI
;
Mitsuru MORI
;
Akiko TAMAKOSHI
Author Information
1. Department of Public Health Medicine, Bielefeld University School of Public Health, Bielefeld, Germany. mobarak.khan@uni-bielefeld.de
- Publication Type:Original Article
- Keywords:
Japan;
Marital status;
Ovarian cancer;
Prospective cohort study;
Reproductive history
- MeSH:
Aged;
Asian Continental Ancestry Group;
Body Mass Index;
Cohort Studies;
Female;
Humans;
Japan;
Marital Status;
Ovarian Neoplasms;
Overweight;
Reproductive History
- From:Journal of Gynecologic Oncology
2013;24(3):249-257
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study mainly aimed to investigate the association of ovarian cancer mortality with reproductive factors and body mass index among Japanese women aged 40-79 years. METHODS: The source of the data was the Japan Collaborative Cohort (JACC) study which covered the period of 1988 to 2009. A representative sample of 64,185 women was used. Cox model was used to estimate the relative risk (RR) and 95% confidence interval (CI). RESULTS: The total number of ovarian cancer deaths was 98, with a mortality rate of 9.30 per 100,000 person-years. Women with single marital status revealed significantly higher age-adjusted RR (RR, 4.11; 95% CI, 1.66 to 10.23; p=0.005) as compared to married women. The effect of single marital status was stronger among older women aged 50+ years (RR, 4.58; 95% CI, 1.65 to 12.72; p=0.003) than younger women. An elevated risk was found for both nulliparous and nullipregnant women. Similarly, an increased risk of ovarian cancer mortality was estimated among overweight among aged 50 years or less. CONCLUSION: Out of many factors only single marital status indicated a higher risk for ovarian cancer mortality. All other factors provided inconclusive results, which imply further epidemiological investigations.
