Low HDL cholesterol is associated with increased atherogenic lipoproteins and insulin resistance in women classified with metabolic syndrome.
- Author:
Maria Luz FERNANDEZ
1
;
Jennifer J JONES
;
Daniela ACKERMAN
;
Jacqueline BARONA
;
Mariana CALLE
;
Michael V COMPERATORE
;
Jung Eun KIM
;
Catherine ANDERSEN
;
Jose O LEITE
;
Jeff S VOLEK
;
Mark MCINTOSH
;
Colleen KALYNYCH
;
Wadie NAJM
;
Robert H LERMAN
Author Information
- Publication Type:Original Article
- Keywords: Metabolic syndrome; heart disease risk; low HDL cholesterol; atherogenic lipoproteins; insulin resistance
- MeSH: Adiponectin; Apolipoproteins; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Diet Records; Female; Humans; Insulin; Insulin Resistance; Lipoprotein(a); Lipoproteins; Lipoproteins, LDL; Plasma; Risk Factors
- From:Nutrition Research and Practice 2010;4(6):492-498
- CountryRepublic of Korea
- Language:English
- Abstract: Both metabolic syndrome (MetS) and elevated LDL cholesterol (LDL-C) increase the risk for cardiovascular disease (CVD). We hypothesized that low HDL cholesterol (HDL-C) would further increase CVD risk in women having both conditions. To assess this, we recruited 89 women with MetS (25-72 y) and LDL-C > or = 2.6 mmol/L. To determine whether plasma HDL-C concentrations were associated with dietary components, circulating atherogenic particles, and other risk factors for CVD, we divided the subjects into two groups: high HDL-C (H-HDL) (> or = 1.3 mmol/L, n = 32) and low HDL-C (L-HDL) (< 1.3 mmol/L, n = 57). Plasma lipids, insulin, adiponectin, apolipoproteins, oxidized LDL, Lipoprotein(a), and lipoprotein size and subfractions were measured, and 3-d dietary records were used to assess macronutrient intake. Women with L-HDL had higher sugar intake and glycemic load (P < 0.05), higher plasma insulin (P < 0.01), lower adiponectin (P < 0.05), and higher numbers of atherogenic lipoproteins such as large VLDL (P < 0.01) and small LDL (P < 0.001) than the H-HDL group. Women with L-HDL also had larger VLDL and both smaller LDL and HDL particle diameters (P < 0.001). HDL-C was positively correlated with LDL size (r = 0.691, P < 0.0001) and HDL size (r = 0.606, P < 0.001), and inversely correlated with VLDL size (r = -0.327, P < 0.01). We concluded that L-HDL could be used as a marker for increased numbers of circulating atherogenic lipoproteins as well as increased insulin resistance in women who are already at risk for CVD.
