+764 G/A Mutation of Inhibin-alpha Gene in Korean Patients with Idiopathic Premature Ovarian Failure.
- Author:
Gyoung Hoon LEE
1
;
Young Min CHOI
;
Jong Mi KIM
;
Jin Ju KIM
;
Kyu Ri HWANG
;
Seung Yup KU
;
Kyu Sup LEE
;
Byung Moon KANG
;
Byung Koo YOON
;
Myoung Seok HAN
;
Byung Chul JEE
;
Chang Suk SUH
;
Seok Hyun KIM
;
Jung Gu KIM
;
Shin Yong MOON
Author Information
1. Department of Obstetrics and Gynecology, Gachon Medical School, Korea.
- Publication Type:Original Article
- Keywords:
Premature ovarian failure (POF);
Inhibin-alpha;
+769 G/A variant;
Korean women
- MeSH:
Asian Continental Ancestry Group;
Autoimmune Diseases;
Chromosome Aberrations;
DNA;
Drug Therapy;
Female;
Humans;
Incidence;
Ovariectomy;
Polymerase Chain Reaction;
Polymorphism, Restriction Fragment Length;
Primary Ovarian Insufficiency*
- From:Korean Journal of Obstetrics and Gynecology
2006;49(8):1706-1711
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the incidence of the +769 G/A mutation of inhibin-alpha gene in Korean patients with idiopathic premature ovarian failure. DESIGN: DNA analysis of the mutation. METHODS: One hundred patients with idiopathic premature ovarian failure (POF) were recruited. Patient with known causes of premature ovarian failure were excluded: cytogenetic abnormalities, prior chemotherapy, prior bilateral oophorectomy and autoimmune disease, etc. DNA was extracted from peripheral blood and the +769 G/A variant of Inhibin-alpha gene (INH-alpha) was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism using restriction enzyme BbvI. RESULTS: We didn't find any case of +769 G/A variant in Inhibin-alpha gene in 100 Korean patients with idiopathic POF. CONCLUSION: This result suggests that in contrary to the recent data reported on the Asian population, the +769 G/A variant in inhibin-alpha gene may not exist in Korean patients with idiopathic POF.
