HLA Type in Minimal Lesion Nephrotic Syndrome (MLNS) in Childhood.
10.3349/ymj.1981.22.2.133
- Author:
Pyung Kil KIM
1
;
Duk Jin YUN
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Minimal lesion nephrotic syndrome;
Human Lymphocytes Antigen
- MeSH:
Glomerulonephritis/immunology;
HLA Antigens/analysis*;
Human;
Nephrosis, Lipoid/immunology*
- From:Yonsei Medical Journal
1981;22(2):133-136
- CountryRepublic of Korea
- Language:English
-
Abstract:
Association of HLA antigens with certain diseases provide insights into genetically determined susceptibility to disease. Although nephrotic syndrome is one of the commonest diseases, it is poorly understood. A group of 57 patients suffering from a minimal lesion nephrotic syndrome (33 patients) and mesangioproliferative glomerulonephritis (24 patients) was studied for immunologic markers. The incidence of HLA-A w 24 is significantly greater in the minimal lesion nephrotic syndrome patients than in controls (18.7% in patients, 0% in controls, p < 0.01). This report fails to show a high incidence of specific HLA antigen in mesangioproliferative glomerulonephritis patients. We believe that the high incidence of HLA-Aw 24 in minimal lesion nephrotic syndrome is indicative of a congenital predisposition to nephrotic syndrome.
