Epidemiologic Characteristics of T Serotyping in Relation to the Outbreak of Erythromycin Resistant Streptocccus pyogenes.
- Author:
Sung Ho CHA
1
;
Kyu Jam HWANG
;
Young Hee LEE
Author Information
1. Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Streptococcus pyogenes;
Erythromycin;
T serotype;
Antibiotic sensitivity test;
Epidemiology
- MeSH:
Epidemiology;
Epitopes;
Erythromycin*;
Humans;
Immune Sera;
Mass Screening;
Pharynx;
Population Characteristics;
Serotyping*;
Streptococcal Infections;
Streptococcus pyogenes;
Tetracycline
- From:Journal of the Korean Pediatric Society
2000;43(10):1323-1329
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The identification of antigenic specificity of Streptococcus pyogenes using T serotyping is important to understand biologic characteristics of microorganisrns. We would like to disover the association of the occurrence of predominant T type, with possible outbreak of erythromycin resistant Streptococcus pyogenes in this country, which has been documented since the late 1990s. METHODS: Throat swab cultures were taken from a total of 1,294 normal school children(Subject A) in two different geographical areas. A total of 92 strains(Subject B) were obtained from the patients with group A streptococcal infections from Jan. 1998 to Dec. 1998. All strains were serotyped with T protein antisera. RESULTS: The distribution of T12 in Uljin increased from 4.2%(1996) to 45.7%(1998). T4 increased from 6.3% to 20.0%. Thirty-eight out of 92 strains were resistant to erythromycin. Twenty-seven out of 41 strains(T12) were multidrug resistant to erythromycin, clindarnycin, and tetracycline. CONCLUSION: We can see the sudden increase in T12 strains, one of the strains that are resistant to erythromycin in 1998, compared with previous years. T protein serotyping could be epidemiologically useful as a screening methods for detecting erythromycin resistant group A streptococci in hospitals where the routine antibiotic sensitivity test dose not examin for streptococci.
