Non-Alcoholic Fatty Liver Disease and Colonic Neoplasm.
10.3904/kjm.2013.84.3.360
- Author:
Jong Wook KIM
1
;
Jeong Sik BYEON
Author Information
1. Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jsbyeon@amc.seoul.kr
- Publication Type:Editorial
- Keywords:
Non-alcoholic fatty liver disease;
Colorectal neoplasm;
Metabolic syndrome
- MeSH:
Adenoma;
Cell Proliferation;
Colon;
Colonic Neoplasms;
Colonoscopy;
Colorectal Neoplasms;
Fatty Liver;
Glucose;
Humans;
Incidence;
Korea;
Mass Screening;
Obesity, Abdominal;
Stress, Physiological;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Medicine
2013;84(3):360-362
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The incidence of colorectal neoplasm including adenomas and carcinomas is increasing in Korea. It has been reported that certain components of the metabolic syndrome including abdominal obesity and abnormal glucose metabolism are associated with increased risk for colorectal cancer. The mechanism involved is most likely linked to metabolic stress, which is associated with increased levels of insulin-like growth factor-1 and TNF-alpha, which promote cell proliferation and survival. Non-alcoholic fatty liver disease (NAFLD) is commonly referred to as the hepatic manifestation of the metabolic syndrome. The study by Lee et al. showed that NAFLD is associated with increased risk for colonic neoplasm. Further studies are needed to decide whether patients with NAFLD require a screening colonoscopy at a younger age than currently recommended.
