Relationship of Non-Alcoholic Fatty Liver Disease to Colorectal Neoplasia.
10.3904/kjm.2013.84.3.363
- Author:
Jue Yong LEE
1
;
Ja Won KIM
Author Information
1. Department of Internal Medicine, Changwon Fatima Hospital, Changwon, Korea. vastus1@hanafos.com
- Publication Type:Original Article
- Keywords:
Non-alcoholic fatty liver disease;
Colorectal neoplasms;
Early detection of cancer
- MeSH:
Adenomatous Polyps;
Blood Pressure;
Body Mass Index;
Colonoscopy;
Colorectal Neoplasms;
Diabetes Mellitus;
Early Detection of Cancer;
Fasting;
Fatty Liver;
Glucose;
Humans;
Hypertension;
Incidental Findings;
Logistic Models;
Male;
Mass Screening;
Prevalence;
Uric Acid;
Waist Circumference
- From:Korean Journal of Medicine
2013;84(3):363-371
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Metabolic syndrome is associated with an increased risk of colorectal cancer. Non-alcoholic fatty liver disease (NAFLD) is regarded as a hepatic manifestation of metabolic syndrome. Increased echogenicity suggesting NAFLD is a frequent incidental finding on ultrasound examination. This study examined whether NAFLD is related to colorectal neoplasia. METHODS: We reviewed 1,938 consecutive individuals who underwent screening colonoscopy at Changwon Fatima Hospital between Jan 2009 and Sept 2011. The individuals were divided into adenomatous polyp (Group A; n = 494) and control (Group B; n = 1,444) groups. NAFLD was diagnosed by increased echogenicity on abdominal ultrasound. RESULTS: The prevalence of NAFLD was 171 (34.6%) in group A and 336 (23.3%) in group B. Compared with normal subjects, group A subjects were more likely to be men, older, and have a higher body mass index (BMI), blood pressure, waist circumference, fasting glucose, uric acid, triglyceride, HbA1c, Hb and gammaGT levels, and a higher prevalence of NAFLD, metabolic syndrome, diabetes mellitus, and hypertension. In a multiple logistic regression analysis, older age (> or = 50 years) (OR 2.051; 95% CI 1.647-2.553), male sex (OR 2.419; 95% CI 1.837-3.184), and prevalence of NAFLD (OR 1.289; 95% CI 1.004-1.655) were associated with an increased risk of adenomatous polyps. CONCLUSIONS: NAFLD is associated with a high prevalence of colorectal neoplasia. A fatty liver on abdominal ultrasound might predict the development of colorectal adenomatous polyps and cancer.
