New Aspects of Vascular Calcification: Histone Deacetylases and Beyond.
10.3346/jkms.2017.32.11.1738
- Author:
Duk Hwa KWON
1
;
Young Kook KIM
;
Hyun KOOK
Author Information
1. Department of Pharmacology, Chonnam National University Medical School, Gwangju, Korea. kookhyun@jnu.ac.kr
- Publication Type:Review
- Keywords:
Vascular Calcification;
Histone Deacetylase;
MDM2;
Posttranslational Modification
- MeSH:
Aging;
Arteries;
Calcium;
Cardiovascular Diseases;
Epigenomics;
Histone Deacetylases*;
Histones*;
Metabolic Diseases;
Mortality;
Osteogenesis;
Protein Processing, Post-Translational;
Protein Stability;
Risk Factors;
Vascular Calcification*
- From:Journal of Korean Medical Science
2017;32(11):1738-1748
- CountryRepublic of Korea
- Language:English
-
Abstract:
Vascular calcification is a pathologic phenomenon in which calcium phosphate is ectopically deposited in the arteries. Previously, calcification was considered to be a passive process in response to metabolic diseases, vascular or valvular diseases, or even aging. However, now calcification is recognized as a highly-regulated consequence, like bone formation, and many clinical trials have been carried out to elucidate the correlation between vascular calcification and cardiovascular events and mortality. As a result, vascular calcification has been implicated as an independent risk factor in cardiovascular diseases. Many molecules are now known to be actively associated with this process. Recently, our laboratory found that posttranslational modification of histone deacetylase (HDAC) 1 is actively involved in the development of vascular calcification. In addition, we found that modulation of the activity of HDAC as well as its protein stability by MDM2, an HDAC1-E3 ligase, may be a therapeutic target in vascular calcification. In the present review, we overview the pathomechanism of vascular calcification and the involvement of posttranslational modification of epigenetic regulators.
