Hypogonadism Makes Dyslipidemia in Klinefelter's Syndrome.
10.3346/jkms.2017.32.11.1848
- Author:
Hyo Serk LEE
1
;
Chan Woo PARK
;
Joong Shik LEE
;
Ju Tae SEO
Author Information
1. Department of Urology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea. jtandro@cgh.co.kr
- Publication Type:Original Article
- Keywords:
Dyslipidemia;
Hypogonadism;
Klinefelter's Syndrome
- MeSH:
Body Composition;
Body Weight;
Cholesterol;
Cholesterol, HDL;
Cholesterol, LDL;
Diagnosis;
Dyslipidemias*;
Humans;
Hypogonadism*;
Infertility;
Klinefelter Syndrome*;
Lipoproteins;
Mass Screening;
Prevalence;
Testosterone;
Triglycerides
- From:Journal of Korean Medical Science
2017;32(11):1848-1851
- CountryRepublic of Korea
- Language:English
-
Abstract:
Klinefelter's syndrome (KS) is a genetic syndrome that presents with hypogonadism and is associated with metabolic syndrome. Patients demonstrating hypogonadism show a greater prevalence of metabolic syndrome due to changes in body composition. We aimed to determine the association between KS and dyslipidemia. The KS group comprised 55 patients who visited the infertility clinic for an infertility evaluation and were confirmed as having a diagnosis of KS. The control group comprised 120 patients who visited the clinic for health screening. Patient characteristics were compared between the two groups with respect to height, weight, body mass index (BMI), testosterone, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride (TG) levels. Height and weight were significantly greater in patients belonging to the KS group, but no statistically significant difference was found with respect to the BMI. Testosterone levels in patients belonging to the KS group were significantly lower compared to the control group (2.4 ± 2.6 vs. 5.2 ± 1.8 ng/mL, P < 0.001). Compared to the control group, TG levels in patients belonging to the KS group were increased (134.9 ± 127.8 vs. 187.9 ± 192.1 mg/dL, P = 0.004) and HDL cholesterol was significantly decreased (51.2 ± 22.0 vs. 44.0 ± 9.5 mg/dL, P = 0.009). LDL cholesterol and total cholesterol were not significantly different between the two groups (P = 0.076 and P = 0.256, respectively). Significant differences were noted between patients belonging to the KS group and normal control group with respect to elevated TG and decreased HDL cholesterol levels.