Accelerated Partial Breast Irradiation with Intensity-Modulated Radiotherapy Is Feasible for Chinese Breast Cancer Patients.
10.4048/jbc.2014.17.3.256
- Author:
Zhenyu HE
1
;
Sangang WU
;
Juan ZHOU
;
Fengyan LI
;
Jiayan SUN
;
Qin LIN
;
Huanxin LIN
;
Xunxing GUAN
Author Information
1. Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. hezhy@sysucc.org.cn
- Publication Type:Original Article
- Keywords:
Breast neoplasms;
Intensity-modulated radiotherapy;
Segmental mastectomy
- MeSH:
Asian Continental Ancestry Group*;
Breast Neoplasms*;
Breast*;
Edema;
Erythema;
Female;
Fibrosis;
Follow-Up Studies;
Humans;
Mastectomy, Segmental;
Neoplasm Metastasis;
Pigmentation;
Prescriptions;
Radiotherapy;
Radiotherapy, Intensity-Modulated*;
Recurrence
- From:Journal of Breast Cancer
2014;17(3):256-264
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Several accelerated partial breast irradiation (APBI) techniques are being investigated in patients with early-stage breast cancer. The present study evaluated the feasibility, early toxicity, initial efficacy, and cosmetic outcomes of accelerated partial breast intensity-modulated radiotherapy (IMRT) for Chinese female patients with early-stage breast cancer after breast-conserving surgery. METHODS: A total of 38 patients met the inclusion criteria and an accelerated partial breast intensity-modulated radiotherapy (APBI-IMRT) plan was designed for each patient. The prescription dose was 34 Gy in 10 fractions, 3.4 Gy per fraction, twice a day, in intervals of more than 6 hours. RESULTS: Of the 38 patients, six patients did not meet the planning criteria. The remaining 32 patients received APBI-IMRT with a mean target volume conformity index of 0.67 and a dose homogeneity index of 1.06. The median follow-up time was 53 months and no local recurrence or distant metastasis was detected. The most common acute toxicities observed within 3 months after radiotherapy were erythema, breast edema, pigmentation, and pain in the irradiated location, among which 43.8%, 12.5%, 31.3%, and 28.1% were grade 1 toxicities, respectively. The most common late toxicities occurring after 3 months until the end of the follow-up period were breast edema, pigmentation, pain in the irradiated location, and subcutaneous fibrosis, among which 6.2%, 28.1%, 21.9%, and 37.5% were grade 1 toxicities, respectively. Thirty-one patients (96.8%) had fine or excellent cosmetic outcomes, and only one patient had a poor cosmetic outcome. CONCLUSION: It is feasible for Chinese females to receive APBI-IMRT after breast conserving surgery. The radiotherapeutic toxicity is acceptable, and both the initial efficacy and cosmetic outcomes are good.
