A Disrupted-in-Schizophrenia 1 Gene Variant is Associated with Clinical Symptomatology in Patients with First-Episode Psychosis.
- Author:
Javier VAZQUEZ-BOURGON
1
;
Ignacio MATA
;
Roberto ROIZ-SANTIANEZ
;
Rosa AYESA-ARRIOLA
;
Paula SUAREZ PINILLA
;
Diana TORDESILLAS-GUTIERREZ
;
Jose Luis VAZQUEZ-BARQUERO
;
Benedicto CRESPO-FACORRO
Author Information
- Publication Type:Original Article
- Keywords: DISC1 ser704cys; Genetics; Hallucinations; Schizophrenia; Severity of illness
- MeSH: Alleles; Brain; Genetics; Hallucinations; Humans; Psychotic Disorders*; Schizophrenia; Weights and Measures
- From:Psychiatry Investigation 2014;11(2):186-191
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: DISC1 gene is one of the main candidate genes for schizophrenia since it has been associated to the illness in several populations. Moreover, variations in several DISC1 polymorphisms, and in particular Ser704Cys SNP, have been associated in schizophrenic patients to structural and functional modifications in two brain areas (pre-frontal cortex and hippocampus) that play a central role in the genesis of psychotic symptoms. This study tested the association between Ser704Cys DISC1 polymorphism and the clinical onset of psychosis. METHODS: Two hundred and thirteen Caucasian drug-naive patients experiencing a first episode of non-affective psychosis were genotyped for rs821616 (Ser704Cys) SNP of the DISC1 gene. The clinical severity of the illness was assessed using SAPS and SANS scales. Other clinical and socio-demographic variables were recorded to rule out possible confounding effects. RESULTS: Patients homozygous for the Ser allele of the Ser704Cys DISC1 SNP had significantly (p<0.05) higher rates at the positive symptoms dimension (SAPS-SANS scales) and hallucinations item, compared to Cys carriers. CONCLUSION: DISC1 gene variations may modulate the clinical severity of the psychosis at the onset of the disorder.
