The Study of Renal Perfusion Image in Rabbit by Harmonic Ultrasound with Microbble Contrast Agent in Comparison with 99mTc-DTPA: Focusing on US Scan Technique and Concentration of Contrast Agent.
10.3348/jkrs.2003.48.2.181
- Author:
Hyo Won EUN
1
;
Jung Hoon KIM
;
Jae Ho CHOI
;
Hun Jae LEE
;
In Young BAE
;
Chung Sik RHEE
;
Jeong Soo SUH
Author Information
1. Department of Radiology, School of Medicine, Soonchunhyang University, Korea. junghkim@hosp.sch.ac.kr
- Publication Type:Original Article
- Keywords:
Ultrasound (US), contrast media;
Kidney, radionuclide studies
- MeSH:
Contrast Media;
Microbubbles;
Perfusion Imaging;
Perfusion*;
Rabbits;
Ultrasonography*
- From:Journal of the Korean Radiological Society
2003;48(2):181-187
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To compare the results of harmonic ultrasound (US) renal perfusion imaging using 99mTc-DTPA as contrast agent with those obtained when a microbubble contrast medium was used. MATERIALS AND METHODS: Twenty rabbits underwent harmonic US renal perfusion imaging using 99mTc-DTPA as contrast agent, and the imaging procedure was then repeated using a microbubble contrast medium. Three different concentrations of contrast media (200, 300 and 400 mg/ml) and two different scanning techniques (intermittent and continuous) were used, and the images obtained were assessed using six different methods. By means of a computer program, the images were converted to a renal perfusion curve and Tpeak values were calculated. Images obtained after use of the two different contrast media were compared. RESULTS: Tpeak at renal perfusion imaging using 99mTc-DTPA was 6.3+/-0.9 sec, and where microbubble contrast agent was used, the findings were was as follows: 13.8+/-1.6 sec (method 1), 6.5+/-1.1 sec (method 2), 14.8+/-1.7 sec (method 3), 6.6+/-1.0 sec (method 4), 15.2+/-2.0 sec (method 5), 6.4+/-0.7 sec (method 6). Method 6 had the highest correlation coefficients. CONCLUSION: In conclusion, the harmonic ultrasound renal perfusion images acquired using 99mTc-DTPA were similar to those obtained using microbubble contrast agent. Continuous scanning techniques showed correlation.
