The influence of adjuvant radiotherapy on patterns of failure and survivals in uterine carcinosarcoma.
10.3857/roj.2011.29.4.228
- Author:
Hae Jin PARK
;
Hak Jae KIM
;
Hong Gyun WU
;
Hans KIM
;
Sung Whan HA
;
Soon Beom KANG
;
Yong Sang SONG
;
Noh Hyun PARK
;
Jae Won KIM
- Publication Type:Original Article
- Keywords:
Uterus;
Carcinosarcoma;
Adjuvant radiotherapy;
Treatment failure;
Survival
- MeSH:
Carcinosarcoma;
Gynecology;
Humans;
Hysterectomy;
Lymph Nodes;
Medical Records;
Neoplasm Metastasis;
Obstetrics;
Radiotherapy, Adjuvant;
Recurrence;
Retrospective Studies;
Survival Rate;
Treatment Failure;
Uterus
- From:Radiation Oncology Journal
2011;29(4):228-235
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the impact of postoperative radiotherapy (PORT) on patterns of failure and survivals in uterine carcinosarcoma patients treated with radical surgery. MATERIALS AND METHODS: Between October 1998 and August 2010, 19 patients with stage I-III uterine carcinosarcoma received curative hysterectomy and bilateral salpingo-oophorectomy with or without PORT at Seoul National University Hospital. Their hospital medical records were retrospectively reviewed. PORT and non-PORT groups included 11 and 8 patients, respectively. They were followed for a mean of 22.7 months (range, 7.8 to 126.6 months). RESULTS: At 5 years, the overall survival rates were 51.9% for entire, 61.4% for PORT, and 41.7% for non-PORT groups, respectively. There was no statistical difference between PORT and non-PORT groups with regard to overall survival (p = 0.682). Seven out of 19 (36.8%) patients showed treatment failures, which all happened within 12 months. Although the predominant failures were distant metastasis in PORT group and loco-regional recurrence in non-PORT group, there was no statistically significant difference in loco-regional recurrence-free survival (LRRFS) (p = 0.362) or distant metastasis-free survival (DMFS) (p = 0.548). Lymph node metastasis was found to be a significant prognostic factor in predicting poor LRRFS (p = 0.013) and DMFS (p = 0.021), while the International Federation Gynecology and Obstetrics (FIGO) stage (p = 0.043) was associated with LRRFS. CONCLUSION: Considering that adjuvant radiotherapy after surgical resection was effective to decrease loco-regional recurrence and most treatment failures were distant metastasis, multimodal therapy including surgery, radiotherapy, and chemotherapy might be an optimal treatment for uterine carcinosarcoma patients.
