Comparison of elective inguinal node irradiation techniques in anal cancer.
10.3857/roj.2011.29.4.236
- Author:
Jihye CHA
;
Jinsil SEONG
;
Ki Chang KEUM
;
Chang Geol LEE
;
Woong Sub KOOM
- Publication Type:Original Article
- Keywords:
Anus neoplasms;
Chemoradiotherapy;
Toxicity
- MeSH:
Anus Neoplasms;
Chemoradiotherapy;
Dermatitis;
Electrons;
Follow-Up Studies;
Humans;
Incidence;
Neoplasm Metastasis;
Pelvis;
Retrospective Studies;
Skin
- From:Radiation Oncology Journal
2011;29(4):236-242
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To compare photon thunderbird with deep match (technique 1) with 3-field technique with electron inguinal boost (technique 2) in acute skin toxicity, toxicity-related treatment breaks and patterns of failure in elective inguinal radiation therapy (RT) for curative chemoradiation in anal cancer. MATERIALS AND METHODS: Seventeen patients treated between January 2008 and September 2010 without evidence of inguinal and distant metastasis were retrospectively reviewed. In 9 patients with technique 1, dose to inguinal and whole pelvis area was 41.4 to 45 Gy and total dose was 59.4 Gy. In 8 patients with technique 2, doses to inguinal, whole pelvis, gross tumor were 36 to 41.4 Gy, 36 to 41.4 Gy, and 45 to 54 Gy, respectively. The median follow-up period was 27.6 and 14.8 months in group technique 1 and 2, respectively. RESULTS: The incidences of grade 3 radiation dermatitis were 56% (5 patients) and 50% (4 patients), dose ranges grade 3 dermatitis appeared were 41.4 to 50.4 Gy and 45 to 54 Gy in group technique 1 and 2, respectively (p = 0.819). The areas affected by grade 3 dermatitis in 2 groups were as follow: perianal and perineal areas in 40% and 25%, perianal and inguinal areas in 0% and 50%, and perianal area only in 60% and 25%, respectively (p = 0.196). No inguinal failure has been observed. CONCLUSION: Photon thunderbird with deep match technique and 3-field technique with electron inguinal boost showed similar incidence of radiation dermatitis. However, photon thunderbird with deep match seems to increase the possibility of severe perineal dermatitis.
