Improving Effect of the Acute Administration of Dietary Fiber-Enriched Cereals on Blood Glucose Levels and Gut Hormone Secretion.
10.3346/jkms.2016.31.2.222
- Author:
Eun Ky KIM
1
;
Tae Jung OH
;
Lee Kyung KIM
;
Young Min CHO
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ymchomd@snu.ac.kr
- Publication Type:Clinical Trial ; Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Dietary Fiber;
Incretins, Glucagon-like Peptide 1;
Diabetes Mellitus, Type 2
- MeSH:
Adult;
Aged;
Area Under Curve;
Blood Glucose/*analysis;
Cross-Over Studies;
Diabetes Mellitus, Type 2/complications/diagnosis/*diet therapy;
Dietary Fiber/*therapeutic use;
Female;
Gastric Inhibitory Polypeptide/blood;
Glucagon/blood;
Glucagon-Like Peptide 1/*blood;
Hemoglobin A, Glycosylated/analysis;
Humans;
Hyperglycemia/complications/diagnosis;
Insulin/blood;
Intestines/metabolism;
Male;
Middle Aged;
ROC Curve
- From:Journal of Korean Medical Science
2016;31(2):222-230
- CountryRepublic of Korea
- Language:English
-
Abstract:
Dietary fiber improves hyperglycemia in patients with type 2 diabetes through its physicochemical properties and possible modulation of gut hormone secretion, such as glucagon-like peptide 1 (GLP-1). We assessed the effect of dietary fiber-enriched cereal flakes (DC) on postprandial hyperglycemia and gut hormone secretion in patients with type 2 diabetes. Thirteen participants ate isocaloric meals based on either DC or conventional cereal flakes (CC) in a crossover design. DC or CC was provided for dinner, night snack on day 1 and breakfast on day 2, followed by a high-fat lunch. On day 2, the levels of plasma glucose, GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and insulin were measured. Compared to CC, DC intake exhibited a lower post-breakfast 2-hours glucose level (198.5±12.8 vs. 245.9±15.2 mg/dL, P<0.05) and a lower incremental peak of glucose from baseline (101.8±9.1 vs. 140.3±14.3 mg/dL, P<0.001). The incremental area under the curve (iAUC) of glucose after breakfast was lower with DC than with CC (P<0.001). However, there were no differences in the plasma insulin, glucagon, GLP-1, and GIP levels. In conclusion, acute administration of DC attenuates postprandial hyperglycemia without any significant change in the representative glucose-regulating hormones in patients with type 2 diabetes (ClinicalTrials.gov. NCT 01997281).
