Negative-pressure Pulmonary Edema by Doxapram-induced Larygospasm: A case report.
10.4097/kjae.2008.54.2.225
- Author:
Jung Kook SUH
1
;
Jong Hoon YEOM
;
Dong Jun BAE
Author Information
1. Department of Anesthesiology and Pain Medicine, School of Medicine, Hanyang University, Seoul, Korea. yeomjh@hanyang.ac.kr
- Publication Type:Case Report
- MeSH:
Airway Obstruction;
Central Nervous System;
Depression;
Doxapram;
Laryngismus;
Pulmonary Edema;
Respiratory Rate;
Tidal Volume;
Vomiting
- From:Korean Journal of Anesthesiology
2008;54(2):225-228
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Doxapram is a peripheral and central respiratory stimulant, producing an increase in tidal volume and a slight increase in respiratory rate. It can temporarily overcome drug-induced respiratory and central nervous system depression, including that seen immediately postoperatively. However, it can also cause side effects, including laryngospasm and vomiting postoperatively. Doxapram-induced laryngospasm causes the increased respiratory efforts to induce more negative pleural pressure, thus causing a negative-pressure pulmonary edema.Therefore, doxapram should not be used if signs of upper airway obstruction are present.
