Comparison of Clinical Outcome According to the Duration of Corticosteroid Therapy in Childhood Henoch-Schonlein Purpura: a Bicentric Stud y.
- Author:
Su Jin LEE
1
;
Jae Il SHIN
;
Chong Guk LEE
;
Kee Hyuck KIM
Author Information
1. Department of Pediatrics, NHIC Ilsan Hospital, Koyang, Korea. kkim@nhimc.or.kr
- Publication Type:Original Article
- Keywords:
Henoch-Schonlein purpura;
Corticosteroid;
Duration;
Nephritis;
Relapse
- MeSH:
Abdominal Pain;
Adrenal Cortex Hormones;
Arthralgia;
Body Weight;
Child;
Hematocrit;
Hemoglobins;
Humans;
Incidence;
Korea;
Leukocyte Count;
Nephritis;
Platelet Count;
Prednisolone;
Purpura, Schoenlein-Henoch;
Recurrence;
Retrospective Studies
- From:Journal of the Korean Society of Pediatric Nephrology
2008;12(2):170-177
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to evaluate whether the incidence of relapse or nephritis might be influenced by the duration of corticosteroid therapy in children with Henoch-Schonlein purpura(HSP). METHODS: We retrospectively analyzed 186 children with a diagnosis of HSP in two major hospitals in Ilsan, Korea from the years 2000 to 2003. To evaluate whether renal involvement or relapse might be influenced by the duration of corticosteroid therapy in children with HSP, one pediatric nephrologist from hospital A, maintained corticosteroid therapy for at least 2 weeks(Group A, n=94). The other from hospital B used only during the symptomatic period(Group B, n=92). RESULTS: There were no significant differences in age, sex, body weight, white blood cell count, hemoglobin, hematocrit, platelet count, serum protein and albumin levels between the two groups. The incidence of abdominal pain or arthralgia also did not differ between two groups. However, the duration of steroid therapy was significantly longer in Group A than in Group B and the cumulative dose of prednisolone was also higher in Group A than in Group B. The development of nephritis was more frequent in Group A. CONCLUSION: The longer duration of steroid use was not associated with the decreased rate of nephritis. Therefore, corticosteroids should be used carefully in a selected group of HSP children, and be tapered rapidly after control of the acute symptoms.
