Primary Diffuse Leptomeningeal Gliomatosis: Report of a Case Presenting with Chronic Meningitis.

Author: Sung Hun KIM ¹ ; Dong Chul JUN ; Jin Se PARK ; Jae Hyeok HEO ; Sung Min KIM ; Juhan KIM ; Sun Ha PAEK ; Manho KIM
Author Information

1. Department of Neurology, Seoul National University College of Medicine, Seoul, Korea. kimmanho@snu.ac.kr
Publication Type:Case Report
Keywords: Primary diffuse leptomeningeal gliomatosis; Chronic meningitis
MeSH: Biopsy; Cerebrospinal Fluid; Glioma; Humans; Meningitis*
From:Journal of Clinical Neurology 2006;2(3):202-205
CountryRepublic of Korea
Language:English
Abstract: Neoplastic meningitis occurs in approximately 5% of patients with cancer. Primary diffuse leptomeningeal gliomatosis is a rare condition whereby a glioma arises from heterotopic cell nests in the leptomeninges. We report here a case presenting with clinical features similar to those of chronic infectious meningitis without positive cerebrospinal fluid cytology. Neurological signs in our patient deteriorated progressively without responding to antitubercular, antiviral, or antibiotic therapy. Leptomeningeal biopsy sampling revealed the condition to be primary diffuse leptomeningeal gliomatosis.