Comparative Study between Glycopyrrolate-Neostigmine and Atropine-Neostigmine in Postanesthetic Arousal .
10.4097/kjae.1986.19.1.66
- Author:
Young Chae YANG
1
;
Yoon Kang SONG
;
Tai Yo KIM
Author Information
1. Department of Anesthesiology, School of Medicine, Won Kwang University, Iri, Korea.
- Publication Type:Comparative Study ; Original Article
- MeSH:
Ammonium Compounds;
Arousal*;
Atropine;
Blood-Brain Barrier;
Cholinergic Antagonists;
Glycopyrrolate;
Neuromuscular Blockade
- From:Korean Journal of Anesthesiology
1986;19(1):66-70
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Atropine and glycopyrrolate have been used for the reversal of non-depolarizing neuromuscular blockade as anticholinergics. Atropine may produce the central anticholinergic effect because it is a tertiary amine which can cross the blood-brain barrier. Glycopyrrolate is a quaternary ammonium compound that does not cross the blood-brain barrier. and as a result, it has no significant central anticholinergic effect. This report compares postanesthetic arousal between glycopyrrolate-neostigmine and atropine-neostigmine mixtures. We conclude that the glycopyrrolate-neostigmine mixture group have significantly more rapid arousal than the atropine-neostigmine group.
