Effect of Fenofibrate Therapy on Blood Creatinine Levels in Patients with Hypertension and Hypertriglyceridemia.
- Author:
Jun Hwan CHO
1
;
Young Hwan CHOI
;
Cheol Won HYEON
;
Kyung Joon KIM
;
Seonghyup HYUN
;
Jee Eun KWON
;
Eun Young KIM
;
Wang Soo LEE
;
Kwang Je LEE
;
Sang Wook KIM
;
Tae Ho KIM
;
Chee Jeong KIM
Author Information
- Publication Type:Original Article
- Keywords: Fenofibrate; Creatinine; Hypertension; Hypertriglyceridemia
- MeSH: Creatinine; Fenofibrate; Follow-Up Studies; Humans; Hypertension; Hypertriglyceridemia; Linear Models; Retrospective Studies
- From:Journal of Lipid and Atherosclerosis 2013;2(1):19-26
- CountryRepublic of Korea
- Language:Korean
- Abstract: OBJECTIVE: Previous studies have reported that fenofibrate therapy increased blood creatinine levels. We investigated the effect of fenofibrate therapy on creatinine levels in patients with hypertension and hypertriglyceridemia. METHODS: This retrospective study included 36 hypertensive patients with hypertriglyceridemia taking fenofibrate for 1-3 years (Fenofibrate group) and 36 control patients with similar age, sex, follow-up duration, creatinine levels, and lipid levels to those of fenofibrate therapy (Control group). RESULTS: Baseline parameters except lipid profiles were similar between the fenofibrate and control groups. Creatinine levels increased in the fenofibrate group (from 0.90+/-0.18 mg/dL to 1.05+/-0.22 mg/dL, p<0.001) and did not change in the control group (from 0.91+/-0.12 mg/dL to 0.92+/-0.14 mg/dL, p=0.39). The elevation was more pronounced in the fenofibrate group than in the control group (0.15+/-0.12 vs. 0.02+/-0.11 mg/dL, p<0.001). Changes in creatinine levels were only associated with fenofibrate therapy (r=0.52, p<0.001) in the stepwise linear regression analysis. CONCLUSION: Fenofibrate therapy for 1-3 years significantly increased creatinine levels in hypertensive patients with hypertriglyceridemia. This finding suggests that follow-up measurement of creatinine level is necessary with fenofibrate therapy.
