Overview of IgG4-Related Tubulointerstitial Nephritis and Its Mimickers.
- Author:
Hyeon Joo JEONG
1
;
Su Jin SHIN
;
Beom Jin LIM
Author Information
- Publication Type:Review
- Keywords: IgG4-related disease; Lupus nephritis; Sjogren's syndrome; Anti-neutrophil cytoplasmic antibody-associated vasculitis; Glomerulonephritis, membranous
- MeSH: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Diagnosis; Fibrosis; Glomerulonephritis; Glomerulonephritis, Membranous; Lupus Erythematosus, Systemic; Lupus Nephritis; Nephritis, Interstitial*; Plasma Cells; Sjogren's Syndrome; Tin
- From:Journal of Pathology and Translational Medicine 2016;50(1):26-36
- CountryRepublic of Korea
- Language:English
- Abstract: Tubulointerstitial nephritis (TIN) is the most common form of renal involvement in IgG4-related disease. It is characterized by a dominant infiltrate of IgG4-positive plasma cells in the interstitium and storiform fibrosis. Demonstration of IgG4-positive plasma cells is essential for diagnosis, but the number of IgG4-positive cells and the ratio of IgG4-positive/IgG-positive plasma cells may vary from case to case and depending on the methods of tissue sampling even in the same case. IgG4-positive plasma cells can be seen in TIN associated with systemic lupus erythematosus, Sjogren syndrome, or anti-neutrophil cytoplasmic antibody-associated vasculitis, which further add diagnostic confusion and difficulties. To have a more clear view of IgG4-TIN and to delineate differential points from other TIN with IgG4-positive plasma cell infiltrates, clinical and histological features of IgG4-TIN and its mimickers were reviewed. In the rear part, cases suggesting overlap of IgG4-TIN and its mimickers and glomerulonephritis associated with IgG4-TIN were briefly described.
