Radiation Effect on Body Weight and Hematological Changes of Hybrid Mice by Conventional Fraction, Large Abdominal FieldIrradiation.
- Author:
Sung Heon LEE
1
;
Sei One SHIN
;
Myung Se KIM
Author Information
1. Department of Therapeutic Radiology, College of Medicine, Yeung Nam University, Korea.
- Publication Type:Original Article
- Keywords:
Radiation effect;
Hematologic changes;
Large abdominal field
- MeSH:
Animals;
Body Weight*;
Female;
Humans;
Lymphocytes;
Male;
Mammals;
Mice*;
Neutrophils;
Radiation Effects*
- From:Journal of the Korean Society for Therapeutic Radiology
1985;3(2):153-158
- CountryRepublic of Korea
- Language:English
-
Abstract:
Radiation effect on mammals, especially on hematologic changes, has been studied since discovery of x-ay. Various experimental animals were tried for radiobiological studies. 72 hybrid mice with conventional ffaction (5X/week), large abdominal field (2 x3cm, from symphysis pubic to xyphoid process) were used. Body weight was declined gradually by increasing irradiation doses, nadir was about 29.7% in male ; 30.4% in female at 6000 rad irradiation group. Hemoglobin value was nearly normal throughout entire treatment. Significant dropping of WBC count was noted to 40-0% of pretreatment values by only 1000 rad irradiation. Change of differential count was interesting; lymphocyte proportion showed gradual reduction, instead of gradual increasing of segmented neutrophil. Those proportion were reversed after 6000 rad irradiation. Urinary protein tests showed + - +++, showing no correlation with dosage. Application. of our study in clinical combination therapy (radiation + chemotherapy) was discussed.
