Discoid Lupus Erythematosus-like Eruption Induced by Tegafur - Uracil (UFT).
- Author:
Junghee YOON
1
;
Soo Hong SEO
;
Young Chul KYE
;
Hyo Hyun AHN
Author Information
1. Department of Dermatology, College of Medicine, Korea University, Seoul, Korea. gold2000@nate.com
- Publication Type:Case Report
- Keywords:
Discoid lupus erythematosus;
Tegafur;
UFT
- MeSH:
Erythema;
Fluorouracil;
Humans;
Hyperpigmentation;
Keratoderma, Palmoplantar;
Lupus Erythematosus, Discoid;
Tegafur;
Uracil
- From:Korean Journal of Dermatology
2010;48(11):1004-1007
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The second-generation oral anticancer agent UFT is a combination of uracil, which has fluorouracil's (5-FU) degradation-inhibitory effect, and tegafur, which is slowly converted to 5-FU in vivo, and UFT shows a higher 5-FU concentration in the tumor tissues than is achieved by tegafur alone or with comparable doses of intravenous 5-FU. Mucocutaneous side reactions induced by UFT are rare and these include photosensitivity of the lichenoid and eczematous types, acral erythema, hyperpigmentation, palmoplantar keratoderma and scleroderma-like reactions, and discoid lupus erythematosus (DLE)-like eruption. However, there has been no report in the Korean medical literature on patients presenting with a DLE-like eruption associated with UFT. So, we report here a case of DLE-like eruption induced by oral UFT.
