Paraneoplastic Panniculitis in a Patient with Acute Myeloid Leukemia.
- Author:
Dae Hun KIM
1
;
Soo Yeon KIM
;
Myung IM
;
Young LEE
;
Cheol O JOE
;
Young Joon SEO
;
Jeunghoon LEE
Author Information
1. Department of Dermatology, College of Medicine, Chungnam National University, Daejeon, Korea. jhoon@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
Acute myeloid leukemia;
Paraneoplastic panniculitis
- MeSH:
Bone Marrow Examination;
Connective Tissue;
Diagnosis, Differential;
Erythema Induratum;
Erythema Nodosum;
Hematologic Neoplasms;
Hematologic Tests;
Humans;
Inflammation;
Leukemia, Myeloid, Acute;
Lymphoma;
Panniculitis;
Skin;
Subcutaneous Fat
- From:Korean Journal of Dermatology
2010;48(11):1016-1019
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Panniculitis generally indicates a group of diseases whose hallmark is fibrous thickening and chronic inflammation of subcutaneous fat. Various factors seem to induce a similar pathological histology, and morphological differences can be found among the patients diagnosed with the same disease. Paraneoplastic causes account for 3~10% of the cases of panniculitis. The commonest causes of cancer associated panniculitis are hematological malignancies and mostly lymphomas. In this case, we confirmed acute myeloid leukemia by a blood test and bone marrow examination, and with considering the clinical aspects and pathological findings of the skin lesion, and we finally diagnosed the patient as having panniculitis, which seems to be related with acute myeloid leukemia. The obvious clinical symptoms or pathophysiological features of this rare type of panniculitis are not yet fully known, and so making the differential diagnosis is needed to distinguish this malady from erythema nodosum, erythema induratum and various connective tissue disorders with accompanying erythematous subcutaneous nodules. We diagnosed this very rare and interesting case of paraneoplastic panniculitis that seemed to be generated from acute myeloid leukemia. We report here on this case and we review the relevant literature.
