The Effect of DPP-4 Inhibitors on Metabolic Parameters in Patients with Type 2 Diabetes.
10.4093/dmj.2014.38.3.211
- Author:
Eun Yeong CHOE
1
;
Yongin CHO
;
Younjeong CHOI
;
Yujung YUN
;
Hye Jin WANG
;
Obin KWON
;
Byung Wan LEE
;
Chul Woo AHN
;
Bong Soo CHA
;
Hyun Chul LEE
;
Eun Seok KANG
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. edgo@yuhs.ac
- Publication Type:Original Article
- Keywords:
Diabetes mellitus;
DPP-4 inhibitor;
Glycated serum albumin;
Lipids
- MeSH:
Blood Glucose;
C-Reactive Protein;
Cholesterol;
Diabetes Mellitus;
Diabetes Mellitus, Type 2;
Fasting;
Glucose;
Hemoglobin A, Glycosylated;
Humans;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Triglycerides;
Sitagliptin Phosphate
- From:Diabetes & Metabolism Journal
2014;38(3):211-219
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We evaluated the effects of two dipeptidyl peptidase-4 (DPP-4) inhibitors, sitagliptin and vildagliptin, on metabolic parameters in patients with type 2 diabetes mellitus. METHODS: A total of 170 type 2 diabetes patients treated with sitagliptin or vildagliptin for more than 24 weeks were selected. The patients were separated into two groups, sitagliptin (100 mg once daily, n=93) and vildagliptin (50 mg twice daily, n=77). We compared the effect of each DPP-4 inhibitor on metabolic parameters, including the fasting plasma glucose (FPG), postprandial glucose (PPG), glycated hemoglobin (HbA1c), and glycated albumin (GA) levels, and lipid parameters at baseline and after 24 weeks of treatment. RESULTS: The HbA1c, FPG, and GA levels were similar between the two groups at baseline, but the sitagliptin group displayed a higher PPG level (P=0.03). After 24 weeks of treatment, all of the glucose-related parameters were significantly decreased in both groups (P=0.001). The levels of total cholesterol and triglycerides were only reduced in the vildagliptin group (P=0.001), although the sitagliptin group received a larger quantity of statins than the vildagliptin group (P=0.002).The mean change in the glucose- and lipid-related parameters after 24 weeks of treatment were not significantly different between the two groups (P=not significant). Neither sitagliptin nor vildagliptin treatment was associated with a reduction in the high sensitive C-reactive protein level (P=0.714). CONCLUSION: Vildagliptin and sitagliptin exert a similar effect on metabolic parameters, but vildagliptin exerts a more potent beneficial effect on lipid parameters.
