Permeability Parameters Measured with Dynamic Contrast-Enhanced MRI: Correlation with the Extravasation of Evans Blue in a Rat Model of Transient Cerebral Ischemia.
10.3348/kjr.2015.16.4.791
- Author:
Hyun Seok CHOI
1
;
Sung Soo AHN
;
Na Young SHIN
;
Jinna KIM
;
Jae Hyung KIM
;
Jong Eun LEE
;
Hye Yeon LEE
;
Ji Hoe HEO
;
Seung Koo LEE
Author Information
1. Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.
- Publication Type:Brief Communication
- Keywords:
Brain ischemia;
Animal models;
Blood-brain barrier;
Dynamic contrast-enhanced MRI;
Kinetic modeling
- MeSH:
Animals;
Blood-Brain Barrier/pathology;
Capillary Permeability;
Contrast Media;
Disease Models, Animal;
Evans Blue/analysis;
Ischemic Attack, Transient/*diagnosis;
Magnetic Resonance Imaging/instrumentation/*methods;
Male;
Rats;
Rats, Sprague-Dawley;
Stroke/diagnosis
- From:Korean Journal of Radiology
2015;16(4):791-797
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia. MATERIALS AND METHODS: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (K(trans), v(e), and v(p)) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue. RESULTS: All permeability parameters (K(trans), v(e), and v(p)) showed a linear correlation with extravasation of Evans blue. Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001). CONCLUSION: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and K(trans) shows the strongest correlation among the tested parameters.
