The Volumetric MRI Analysis of the Basal Ganglia in Boys with Tourette's Disorder.
- Author:
Young Kyung SUNWOO
1
;
Yong Bum SHIN
;
Myung Ji LEE
;
Jee Young KIM
;
Jae Nam BAE
;
Min Hee KANG
;
Chul Eung KIM
;
Jeong Seop LEE
Author Information
1. Department of Psychiatry, School of Medicine, Inha University, Incheon, Korea. soulfree@inha.ac.kr
- Publication Type:Original Article
- Keywords:
Tourette's disorder;
Basal ganglia;
Putamen;
Globus pallidus
- MeSH:
Basal Ganglia;
Brain;
Diagnostic and Statistical Manual of Mental Disorders;
Globus Pallidus;
Putamen;
Tourette Syndrome
- From:Journal of Korean Neuropsychiatric Association
2008;47(4):311-317
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The purpose of this study was to investigate the regional differences of the basal ganglia volume between the boy subjects who have Tourette's disorder and the control group who don't have this disorder by using Brain MRI. METHODS: Sixteen subjects who were diagnosed as Tourette's disorder using DSM-IV criteria, and sixteen healthy subjects were selected. For analysis the coronal slice images of the basal ganglia were collected and collected MR images were analyzed with NIH Image (version 6.1 ppc). RESULTS: The total brain volume in the subjects with Tourette's disorder were smaller than control group by 6.2% (F=6.2, d.f.=1, p=0.019). The right putamen volume in boys with Tourette's disorder were significant smaller than control group statistically (F=3.2, d.f.=3, p=0.040). The asymmetry (left>right) in the globus pallidus decreased significantly in the boys with Tourette's disorder (p=0.06) were found from this experiment. CONCLUSION: These findings suggest that boys with Tourette's disorder may have neuropathological abnormalities in the basal ganglia. Moreover, the present findings point out the important role of basal ganglia, especially putamen, in pathophysiology of Tourette's disorder. More studies about the structural and functional analysis of the basal ganglia in Tourette's disorder are highly required.
