Meta-analysis of Predictive Clinicopathologic Factors for Lymph Node Metastasis in Patients with Early Colorectal Carcinoma.
10.3346/jkms.2015.30.4.398
- Author:
Ju Young CHOI
1
;
Sung Ae JUNG
;
Ki Nam SHIM
;
Won Young CHO
;
Bora KEUM
;
Jeong Sik BYEON
;
Kyu Chan HUH
;
Byung Ik JANG
;
Dong Kyung CHANG
;
Hwoon Yong JUNG
;
Kyoung Ae KONG
Author Information
1. Department of Internal Medicine, Ewha Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea. jassa@ewha.ac.kr
- Publication Type:Original Article ; Meta-Analysis
- Keywords:
Colorectal Neoplasms;
Lymph Nodes;
Endoscopy;
Colectomy
- MeSH:
Colectomy;
Colorectal Neoplasms/*pathology/surgery;
Endoscopy;
Female;
Humans;
Intestinal Polyps/surgery;
Lymphatic Metastasis;
Male;
Neoplasm Invasiveness
- From:Journal of Korean Medical Science
2015;30(4):398-406
- CountryRepublic of Korea
- Language:English
-
Abstract:
The objective of this study was to conduct a meta-analysis to determine risk factors that may facilitate patient selection for radical resections or additional resections after a polypectomy. Eligible articles were identified by searches of PUBMED, Cochrane Library and Korean Medical Database using the terms (early colorectal carcinoma [ECC], lymph node metastasis [LNM], colectomy, endoscopic resection). Thirteen cohort studies of 7,066 ECC patients who only underwent radical surgery have been analysed. There was a significant risk of LNM when they had submucosal invasion (> or = SM2 or > or = 1,000 microm) (odds Ratio [OR], 3.00; 95% confidence interval [CI], 1.36-6.62, P = 0.007). Moreover, it has been found that vascular invasion (OR, 2.70; 95% CI, 1.95-3.74; P < 0.001), lymphatic invasion (OR, 6.91; 95% CI, 5.40-8.85; P < 0.001), poorly differentiated carcinomas (OR, 8.27; 95% CI, 4.67-14.66; P < 0.001) and tumor budding (OR, 4.59; 95% CI, 3.44-6.13; P < 0.001) were significantly associated with LNM. Furthermore, another analysis was carried out on eight cohort studies of 310 patients who underwent additional surgeries after an endoscopic resection. The major factors identified in these studies include lymphovascular invasion on polypectomy specimens (OR, 5.47; 95% CI, 2.46-12.17; P < 0.001) and poorly or moderately differentiated carcinomas (OR, 4.07; 95% CI, 1.08-15.33; P = 0.04). For ECC patients with > or = SM2 or > or = 1,000 microm submucosal invasion, vascular invasion, lymphatic invasion, poorly differentiated carcinomas or tumor budding, it is deemed that a more extensive resection accompanied by a lymph node dissection is necessary. Even if the lesion is completely removed by an endoscopic resection, an additional surgical resection should be considered in patients with poorly or moderately differentiated carcinomas or lymphovascular invasion.
